1jv2

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[[Image:1jv2.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1jv2| PDB=1jv2 | SCENE= }}
{{STRUCTURE_1jv2| PDB=1jv2 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3'''
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===CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3===
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==Overview==
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Integrins are alphabeta heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution. Its 12 domains assemble into an ovoid "head" and two "tails." In the crystal, alphaVbeta3 is severely bent at a defined region in its tails, reflecting an unusual flexibility that may be linked to integrin regulation. The main inter-subunit interface lies within the head, between a seven-bladed beta-propeller from alphaV and an A domain from beta3, and bears a striking resemblance to the Galpha/Gbeta interface in G proteins. A metal ion-dependent adhesion site (MIDAS) in the betaA domain is positioned to participate in a ligand-binding interface formed of loops from the propeller and betaA domains. MIDAS lies adjacent to a calcium-binding site with a potential regulatory function.
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The line below this paragraph, {{ABSTRACT_PUBMED_11546839}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11546839 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11546839}}
==About this Structure==
==About this Structure==
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[[Category: Psi domain]]
[[Category: Psi domain]]
[[Category: Thigh domain]]
[[Category: Thigh domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:57:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:57:06 2008''

Revision as of 17:57, 1 July 2008

Image:1jv2.png

Template:STRUCTURE 1jv2

CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3

Template:ABSTRACT PUBMED 11546839

About this Structure

1JV2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular segment of integrin alpha Vbeta3., Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA, Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:11546839

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