This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jvk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jvk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1jvk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jvk| PDB=1jvk | SCENE= }}
{{STRUCTURE_1jvk| PDB=1jvk | SCENE= }}
-
'''THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR'''
+
===THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR===
-
==Overview==
+
<!--
-
The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a "Bence-Jones protein" from a patient with multiple myeloma and amyloidosis (Sea) was determined at 1.94 A resolution and refined to R and R(free) factors of 0.22 and 0.25, respectively. This "amyloidogenic" protein crystallized in the orthorhombic P2(1)2(1)2(1) space group with unit-cell parameters a = 48.28, b = 83.32, c = 112.59 A as determined at 100 K. In the vital organs (heart and kidneys), the equivalent of the urinary protein produced fibrillar amyloid deposits which were fatal to the patient. Compared with the amyloidogenic Mcg light-chain dimer, the Sea protein was highly soluble in aqueous solutions and only crystallized at concentrations approaching 100 mg ml(-1). Both the Sea and Mcg proteins packed into crystals in highly ordered arrangements typical of strongly diffracting crystals of immunoglobulin fragments. Overall similarities and significant differences in the three-dimensional structures and crystalline properties are discussed for the Sea and Mcg Bence-Jones proteins, which together provide a generalized model of abnormalities present in lambda chains, facilitating a better understanding of amyloidosis of light-chain origin (AL).
+
The line below this paragraph, {{ABSTRACT_PUBMED_11976493}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11976493 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11976493}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Amyloidogenic]]
[[Category: Amyloidogenic]]
[[Category: Immunoglobulin light chain dimer]]
[[Category: Immunoglobulin light chain dimer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:58:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:00:06 2008''

Revision as of 18:00, 1 July 2008

Image:1jvk.png

Template:STRUCTURE 1jvk

THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR

Template:ABSTRACT PUBMED 11976493

About this Structure

Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties., Bourne PC, Ramsland PA, Shan L, Fan ZC, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB, Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):815-23. Epub 2002, Apr 26. PMID:11976493

Page seeded by OCA on Tue Jul 1 21:00:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jvk"
Personal tools