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1jvm

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[[Image:1jvm.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1jvm| PDB=1jvm | SCENE= }}
{{STRUCTURE_1jvm| PDB=1jvm | SCENE= }}
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'''KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM'''
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===KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM===
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==Overview==
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The K+ selectivity filter catalyses the dehydration, transfer and rehydration of a K+ ion in about ten nanoseconds. This physical process is central to the production of electrical signals in biology. Here we show how nearly diffusion-limited rates are achieved, by analysing ion conduction and the corresponding crystallographic ion distribution in the selectivity filter of the KcsA K+ channel. Measurements with K+ and its slightly larger analogue, Rb+, lead us to conclude that the selectivity filter usually contains two K+ ions separated by one water molecule. The two ions move in a concerted fashion between two configurations, K+-water-K+-water (1,3 configuration) and water-K+-water-K+ (2,4 configuration), until a third ion enters, displacing the ion on the opposite side of the queue. For K+, the energy difference between the 1,3 and 2,4 configurations is close to zero, the condition of maximum conduction rate. The energetic balance between these configurations is a clear example of evolutionary optimization of protein function.
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The line below this paragraph, {{ABSTRACT_PUBMED_11689935}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11689935 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11689935}}
==About this Structure==
==About this Structure==
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[[Category: Metal transport]]
[[Category: Metal transport]]
[[Category: Potassium channel]]
[[Category: Potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:58:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:00:23 2008''

Revision as of 18:00, 1 July 2008

Image:1jvm.png

Template:STRUCTURE 1jvm

KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM

Template:ABSTRACT PUBMED 11689935

About this Structure

1JVM is a Single protein structure of sequence from Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Energetic optimization of ion conduction rate by the K+ selectivity filter., Morais-Cabral JH, Zhou Y, MacKinnon R, Nature. 2001 Nov 1;414(6859):37-42. PMID:11689935

Page seeded by OCA on Tue Jul 1 21:00:23 2008

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