1jvs

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{{STRUCTURE_1jvs| PDB=1jvs | SCENE= }}
{{STRUCTURE_1jvs| PDB=1jvs | SCENE= }}
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'''Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs'''
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===Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs===
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==Overview==
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The key enzyme in the nonmevalonate pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), has been shown to be an effective target of antimalarial drugs. Here we report the crystal structure of DXR complexed with NADPH and a sulfate ion from Escherichia coli at 2.2 A resolution. The structure showed the presence of an extra domain, which is absent from other NADPH-dependent oxidoreductases, in addition to the conformation of catalytic residues and the substrate binding site. A flexible loop covering the substrate binding site plays an important role in the enzymatic reaction and the determination of substrate specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 11872159 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11872159}}
==About this Structure==
==About this Structure==
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[[Category: Nadph]]
[[Category: Nadph]]
[[Category: Reductoisomerase]]
[[Category: Reductoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:59:15 2008''
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Revision as of 18:02, 1 July 2008

Image:1jvs.png

Template:STRUCTURE 1jvs

Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs

Template:ABSTRACT PUBMED 11872159

About this Structure

1JVS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding., Yajima S, Nonaka T, Kuzuyama T, Seto H, Ohsawa K, J Biochem. 2002 Mar;131(3):313-7. PMID:11872159

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