1jyo

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[[Image:1jyo.gif|left|200px]]
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{{Seed}}
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[[Image:1jyo.png|left|200px]]
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{{STRUCTURE_1jyo| PDB=1jyo | SCENE= }}
{{STRUCTURE_1jyo| PDB=1jyo | SCENE= }}
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'''Structure of the Salmonella Virulence Effector SptP in Complex with its Secretion Chaperone SicP'''
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===Structure of the Salmonella Virulence Effector SptP in Complex with its Secretion Chaperone SicP===
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==Overview==
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Many bacterial pathogens use a type III protein secretion system to deliver virulence effector proteins directly into the host cell cytosol, where they modulate cellular processes. A requirement for the effective translocation of several such effector proteins is the binding of specific cytosolic chaperones, which typically interact with discrete domains in the virulence factors. We report here the crystal structure at 1.9 A resolution of the chaperone-binding domain of the Salmonella effector protein SptP with its cognate chaperone SicP. The structure reveals that this domain is maintained in an extended, unfolded conformation that is wound around three successive chaperone molecules. Short segments from two different SptP molecules are juxtaposed by the chaperones, where they dimerize across a hydrophobic interface. These results imply that the chaperones associated with the type III secretion system maintain their substrates in a secretion-competent state that is capable of engaging the secretion machinery to travel through the type III apparatus in an unfolded or partially folded manner.
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The line below this paragraph, {{ABSTRACT_PUBMED_11689946}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11689946 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11689946}}
==About this Structure==
==About this Structure==
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[[Category: Unfolded]]
[[Category: Unfolded]]
[[Category: Virulence factor]]
[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:05:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:07:46 2008''

Revision as of 18:07, 1 July 2008

Image:1jyo.png

Template:STRUCTURE 1jyo

Structure of the Salmonella Virulence Effector SptP in Complex with its Secretion Chaperone SicP

Template:ABSTRACT PUBMED 11689946

About this Structure

1JYO is a Protein complex structure of sequences from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion., Stebbins CE, Galan JE, Nature. 2001 Nov 1;414(6859):77-81. PMID:11689946

Page seeded by OCA on Tue Jul 1 21:07:46 2008

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