1k0m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k0m.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k0m.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k0m| PDB=1k0m | SCENE= }}
{{STRUCTURE_1k0m| PDB=1k0m | SCENE= }}
-
'''Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms'''
+
===Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms===
-
==Overview==
+
<!--
-
CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that exists in both soluble and integral membrane forms. Purified CLIC1 can integrate into synthetic lipid bilayers forming a chloride channel with similar properties to those observed in vivo. The structure of the soluble form of CLIC1 has been determined at 1.4-A resolution. The protein is monomeric and structurally homologous to the glutathione S-transferase superfamily, and it has a redox-active site resembling glutaredoxin. The structure of the complex of CLIC1 with glutathione shows that glutathione occupies the redox-active site, which is adjacent to an open, elongated slot lined by basic residues. Integration of CLIC1 into the membrane is likely to require a major structural rearrangement, probably of the N-domain (residues 1-90), with the putative transmembrane helix arising from residues in the vicinity of the redox-active site. The structure indicates that CLIC1 is likely to be controlled by redox-dependent processes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11551966}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11551966 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11551966}}
==About this Structure==
==About this Structure==
Line 40: Line 44:
[[Category: Chloride ion channel]]
[[Category: Chloride ion channel]]
[[Category: Glutathione-s-tranferase superfamily]]
[[Category: Glutathione-s-tranferase superfamily]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:09:09 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:12:01 2008''

Revision as of 18:12, 1 July 2008

Image:1k0m.png

Template:STRUCTURE 1k0m

Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms

Template:ABSTRACT PUBMED 11551966

About this Structure

1K0M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution., Harrop SJ, DeMaere MZ, Fairlie WD, Reztsova T, Valenzuela SM, Mazzanti M, Tonini R, Qiu MR, Jankova L, Warton K, Bauskin AR, Wu WM, Pankhurst S, Campbell TJ, Breit SN, Curmi PM, J Biol Chem. 2001 Nov 30;276(48):44993-5000. Epub 2001 Sep 10. PMID:11551966

Page seeded by OCA on Tue Jul 1 21:12:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k0m"
Personal tools