1k0x

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{{STRUCTURE_1k0x| PDB=1k0x | SCENE= }}
{{STRUCTURE_1k0x| PDB=1k0x | SCENE= }}
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'''Solution Structure of Melanoma Inhibitory Activity Protein'''
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===Solution Structure of Melanoma Inhibitory Activity Protein===
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==Overview==
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Melanoma inhibitory activity (MIA) is a small secreted protein that is implicated in cartilage cell maintenance and melanoma metastasis. It is representative of a recently discovered family of proteins that contain a Src Homologous 3 (SH3) subdomain. While SH3 domains are normally found in intracellular proteins and mediate protein-protein interactions via recognition of polyproline helices, MIA is single-domain extracellular protein, and it probably binds to a different class of ligands. Here we report the assignments, solution structure, and dynamics of human MIA determined by heteronuclear NMR methods. The structures were calculated in a semi-automated manner without manual assignment of NOE crosspeaks, and have a backbone rmsd of 0.38 A over the ordered regions of the protein. The structure consists of an SH3-like subdomain with N- and C-terminal extensions of approximately 20 amino acids each that together form a novel fold. The rmsd between the solution structure and our recently reported crystal structure is 0.86 A over the ordered regions of the backbone, and the main differences are localized to the most dynamic regions of the protein. The similarity between the NMR and crystal structures supports the use of automated NOE assignments and ambiguous restraints to accelerate the calculation of NMR structures.
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{{ABSTRACT_PUBMED_11991352}}
==About this Structure==
==About this Structure==
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1K0X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0X OCA].
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1K0X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0X OCA].
==Reference==
==Reference==
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[[Category: Lougheed, J C.]]
[[Category: Lougheed, J C.]]
[[Category: Sh3 subdomain]]
[[Category: Sh3 subdomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:14:28 2008''

Revision as of 18:14, 1 July 2008

Template:STRUCTURE 1k0x

Solution Structure of Melanoma Inhibitory Activity Protein

Template:ABSTRACT PUBMED 11991352

About this Structure

1K0X is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and dynamics of melanoma inhibitory activity protein., Lougheed JC, Domaille PJ, Handel TM, J Biomol NMR. 2002 Mar;22(3):211-23. PMID:11991352

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