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1k12

From Proteopedia

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{{STRUCTURE_1k12| PDB=1k12 | SCENE= }}
{{STRUCTURE_1k12| PDB=1k12 | SCENE= }}
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'''Fucose Binding lectin'''
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===Fucose Binding lectin===
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==Overview==
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Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 12091873 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12091873}}
==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Protein carbohydrate complex]]
[[Category: Protein carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:15:18 2008''

Revision as of 18:15, 1 July 2008

Image:1k12.png

Template:STRUCTURE 1k12

Fucose Binding lectin

Template:ABSTRACT PUBMED 12091873

About this Structure

1K12 is a Single protein structure of sequence from Anguilla anguilla. Full crystallographic information is available from OCA.

Reference

A novel fucose recognition fold involved in innate immunity., Bianchet MA, Odom EW, Vasta GR, Amzel LM, Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873

Page seeded by OCA on Tue Jul 1 21:15:18 2008

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