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1k1q

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[[Image:1k1q.gif|left|200px]]
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{{Seed}}
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[[Image:1k1q.png|left|200px]]
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{{STRUCTURE_1k1q| PDB=1k1q | SCENE= }}
{{STRUCTURE_1k1q| PDB=1k1q | SCENE= }}
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'''Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus'''
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===Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus===
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==Overview==
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A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 A resolution crystal structure of the Sulfolobus solfataricus Dbh protein, a DNA translesion polymerase closely related to Escherichia coli DNA polymerase IV and human polymerase kappa. A high error rate is observed for the Dbh polymerase in a range of 10(-2)-10(-3) for all 12 base substitution mispairs. The crystal structure of Dbh reveals an overall architecture resembling other DNA polymerases but has unique features that are likely to contribute to error-prone synthesis, including -1 frameshifting mutations.
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The line below this paragraph, {{ABSTRACT_PUBMED_11685247}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11685247 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685247}}
==About this Structure==
==About this Structure==
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[[Category: Error-prone polymerase]]
[[Category: Error-prone polymerase]]
[[Category: Lesion-bypass polymerase]]
[[Category: Lesion-bypass polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:11:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:18:55 2008''

Revision as of 18:19, 1 July 2008

Image:1k1q.png

Template:STRUCTURE 1k1q

Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus

Template:ABSTRACT PUBMED 11685247

About this Structure

1K1Q is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:11685247

Page seeded by OCA on Tue Jul 1 21:18:55 2008

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