1k2e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k2e.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1k2e.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k2e| PDB=1k2e | SCENE= }}
{{STRUCTURE_1k2e| PDB=1k2e | SCENE= }}
-
'''crystal structure of a nudix protein from Pyrobaculum aerophilum'''
+
===crystal structure of a nudix protein from Pyrobaculum aerophilum===
-
==Overview==
+
<!--
-
Nudix proteins, formerly called MutT homolog proteins, are a large family of proteins that play an important role in reducing the accumulation of potentially toxic compounds inside the cell. They hydrolyze a wide variety of substrates that are mainly composed of a nucleoside diphosphate linked to some other moiety X and thus are called Nudix hydrolases. Here, the crystal structure of a Nudix hydrolase from the hyperthermophilic archaeon Pyrobaculum aerophilum is reported. The structure was determined by the single-wavelength anomalous scattering method with data collected at the peak anomalous wavelength of an iridium-derivatized crystal. It reveals an extensive dimer interface, with each subunit contributing two strands to the beta-sheet of the other subunit. Individual subunits consist of a mixed highly twisted and curved beta-sheet of 11 beta-strands and two alpha-helices, forming an alpha-beta-alpha sandwich. The conserved Nudix box signature motif, which contains the essential catalytic residues, is located at the first alpha-helix and the beta-strand and loop preceding it. The unusually short connections between secondary-structural elements, together with the dimer form of the structure, are likely to contribute to the thermostability of the P. aerophilum Nudix protein.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11914479}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11914479 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11914479}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Putative nudix hydrolase]]
[[Category: Putative nudix hydrolase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:28:48 2008''

Revision as of 18:29, 1 July 2008

Image:1k2e.png

Template:STRUCTURE 1k2e

crystal structure of a nudix protein from Pyrobaculum aerophilum

Template:ABSTRACT PUBMED 11914479

About this Structure

1K2E is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets., Wang S, Mura C, Sawaya MR, Cascio D, Eisenberg D, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):571-8. Epub 2002, Mar 22. PMID:11914479

Page seeded by OCA on Tue Jul 1 21:28:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k2e"
Personal tools