1k32

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k32.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k32.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k32| PDB=1k32 | SCENE= }}
{{STRUCTURE_1k32| PDB=1k32 | SCENE= }}
-
'''Crystal structure of the tricorn protease'''
+
===Crystal structure of the tricorn protease===
-
==Overview==
+
<!--
-
The degradation of cytosolic proteins is carried out predominantly by the proteasome, which generates peptides of 7-9 amino acids long. These products need further processing. Recently, a proteolytic system was identified in the model organism Thermoplasma acidophilum that performs this processing. The hexameric core protein of this modular system, referred to as tricorn protease, is a 720K protease that is able to assemble further into a giant icosahedral capsid, as determined by electron microscopy. Here, we present the crystal structure of the tricorn protease at 2.0 A resolution. The structure reveals a complex mosaic protein whereby five domains combine to form one of six subunits, which further assemble to form the 3-2-symmetric core protein. The structure shows how the individual domains coordinate the specific steps of substrate processing, including channelling of the substrate to, and the product from, the catalytic site. Moreover, the structure shows how accessory protein components might contribute to an even more complex protein machinery that efficiently collects the tricorn-released products.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11719810}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11719810 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11719810}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Substrate gating]]
[[Category: Substrate gating]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:14:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 22:09:01 2008''

Revision as of 19:10, 1 July 2008

Image:1k32.png

Template:STRUCTURE 1k32

Crystal structure of the tricorn protease

Template:ABSTRACT PUBMED 11719810

About this Structure

1K32 is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tricorn protease reveals a protein disassembly line., Brandstetter H, Kim JS, Groll M, Huber R, Nature. 2001 Nov 22;414(6862):466-70. PMID:11719810

Page seeded by OCA on Tue Jul 1 22:09:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k32"
Personal tools