1k4u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k4u.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k4u.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k4u| PDB=1k4u | SCENE= }}
{{STRUCTURE_1k4u| PDB=1k4u | SCENE= }}
-
'''Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox'''
+
===Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox===
-
==Overview==
+
<!--
-
The basic function of the Src homology 3 (SH3) domain is considered to be binding to proline-rich sequences containing a PxxP motif. Recently, many SH3 domains, including those from Grb2 and Pex13p, were reported to bind sequences lacking a PxxP motif. We report here that the 22 residue peptide lacking a PxxP motif, derived from p47(phox), binds to the C-terminal SH3 domain from p67(phox). We applied the NMR cross-saturation method to locate the interaction sites for the non-PxxP peptides on their cognate SH3 domains from p67(phox), Grb2 and Pex13p. The binding site of the Grb2 SH3 partially overlapped the conventional PxxP-binding site, whereas those of p67(phox) and Pex13p SH3s are located in different surface regions. The non-PxxP peptide from p47(phox) binds to the p67(phox) SH3 more tightly when it extends to the N-terminus to include a typical PxxP motif, which enabled the structure determination of the complex, to reveal that the non-PxxP peptide segment interacted with the p67(phox) SH3 in a compact helix-turn-helix structure (PDB entry 1K4U).
+
The line below this paragraph, {{ABSTRACT_PUBMED_12169629}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12169629 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12169629}}
==Disease==
==Disease==
Line 19: Line 23:
==About this Structure==
==About this Structure==
-
1K4U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4U OCA].
+
1K4U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4U OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: P67phox]]
[[Category: P67phox]]
[[Category: Sh3-peptide complex]]
[[Category: Sh3-peptide complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:18:33 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:46:42 2008''

Revision as of 06:46, 2 July 2008

Image:1k4u.png

Template:STRUCTURE 1k4u

Contents

Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox

Template:ABSTRACT PUBMED 12169629

Disease

Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-2 OMIM:[608515], Chronic granulomatous disease due to deficiency of NCF-1 OMIM:[608512]

About this Structure

1K4U is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p., Kami K, Takeya R, Sumimoto H, Kohda D, EMBO J. 2002 Aug 15;21(16):4268-76. PMID:12169629

Page seeded by OCA on Wed Jul 2 09:46:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k4u"
Personal tools