1k5h

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{{STRUCTURE_1k5h| PDB=1k5h | SCENE= }}
{{STRUCTURE_1k5h| PDB=1k5h | SCENE= }}
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'''1-deoxy-D-xylulose-5-phosphate reductoisomerase'''
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===1-deoxy-D-xylulose-5-phosphate reductoisomerase===
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==Overview==
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We have solved the 2.5-A crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, an enzyme involved in the mevalonate-independent 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. The structure reveals that the enzyme is present as a homodimer. Each monomer displays a V-like shape and is composed of an amino-terminal dinucleotide binding domain, a connective domain, and a carboxyl-terminal four-helix bundle domain. The connective domain is responsible for dimerization and harbors most of the active site. The strictly conserved acidic residues Asp(150), Glu(152), Glu(231), and Glu(234) are clustered at the putative active site and are probably involved in the binding of divalent cations mandatory for enzyme activity. The connective and four-helix bundle domains show significant mobility upon superposition of the dinucleotide binding domains of the three conformational states present in the asymmetric unit of the crystal. A still more pronounced flexibility is observed for a loop spanning residues 186 to 216, which adopts two completely different conformations within the three protein conformers. A possible involvement of this loop in an induced fit during substrate binding is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11741911 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11741911}}
==About this Structure==
==About this Structure==
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[[Category: Induced fit]]
[[Category: Induced fit]]
[[Category: Variable loop]]
[[Category: Variable loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:20:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:48:57 2008''

Revision as of 06:48, 2 July 2008

Image:1k5h.png

Template:STRUCTURE 1k5h

1-deoxy-D-xylulose-5-phosphate reductoisomerase

Template:ABSTRACT PUBMED 11741911

About this Structure

1K5H is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis., Reuter K, Sanderbrand S, Jomaa H, Wiesner J, Steinbrecher I, Beck E, Hintz M, Klebe G, Stubbs MT, J Biol Chem. 2002 Feb 15;277(7):5378-84. Epub 2001 Dec 7. PMID:11741911

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