1hng
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(New page: 200px<br /><applet load="1hng" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hng, resolution 2.8Å" /> '''CRYSTAL STRUCTURE AT ...)
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Revision as of 14:33, 20 November 2007
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CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2
Overview
The crystal structure of a soluble form of the T lymphocyte antigen CD2, provides the first complete view of the extracellular region of a cell, adhesion molecule. The topology of the molecule, which comprises two, immunoglobulin-like domains, is the same as that of the first two domains, of CD4 but the relative domain orientation is altered by a fairly flexible, linker region. The putative ligand-binding beta-sheet forms a flat surface, towards the top of the molecule. Crystal contacts between these surfaces, suggest a plausible model for the adhesive interaction.
About this Structure
1HNG is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2., Jones EY, Davis SJ, Williams AF, Harlos K, Stuart DI, Nature. 1992 Nov 19;360(6401):232-9. PMID:1279440
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