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1k5m

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{{STRUCTURE_1k5m| PDB=1k5m | SCENE= }}
{{STRUCTURE_1k5m| PDB=1k5m | SCENE= }}
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'''Crystal Structure of a Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 V3 Loop Chimeric Virus MN-III-2'''
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===Crystal Structure of a Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 V3 Loop Chimeric Virus MN-III-2===
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==Overview==
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We report the 2.7 A resolution structure of a chimeric rhinovirus, MN-III-2, that displays part of the HIV-1 gp120 V3 loop and elicits HIV-neutralizing antibodies. The V3 loop insert is dominated by two type I beta turns. The structures of two adjacent tripeptides resemble those of analogous segments in three Fab/V3 loop peptide complexes. Although two of the three corresponding antibodies bind and neutralize MN-III-2 well, only one of the three can bind without significant rearrangement. These results suggest that the V3 loop insert: (1) can share some local conformational similarity to V3 loop sequences presented on different structural frameworks; (2) must be able to adopt multiple conformations, even in a relatively constrained environment; and (3) may mimic the conformational variability of the epitope on HIV-1, increasing the likelihood of eliciting appropriate neutralizing immune responses.
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(as it appears on PubMed at http://www.pubmed.gov), where 12121655 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12121655}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1 v3 loop]]
[[Category: Hiv-1 v3 loop]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:20:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:49:27 2008''

Revision as of 06:49, 2 July 2008

Image:1k5m.png

Template:STRUCTURE 1k5m

Crystal Structure of a Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 V3 Loop Chimeric Virus MN-III-2

Template:ABSTRACT PUBMED 12121655

About this Structure

1K5M is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1., Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E, Structure. 2002 Jul;10(7):999-1011. PMID:12121655

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