1k5w

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[[Image:1k5w.jpg|left|200px]]
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{{Seed}}
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[[Image:1k5w.png|left|200px]]
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{{STRUCTURE_1k5w| PDB=1k5w | SCENE= }}
{{STRUCTURE_1k5w| PDB=1k5w | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE'''
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===THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE===
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==Overview==
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Synaptotagmin 1 probably functions as a Ca2+ sensor in neurotransmitter release via its two C2-domains, but no common Ca2+-dependent activity that could underlie a cooperative action between them has been described. The NMR structure of the C2B-domain now reveals a beta sandwich that exhibits striking similarities and differences with the C2A-domain. Whereas the bottom face of the C2B-domain has two additional alpha helices that may be involved in specialized Ca2+-independent functions, the top face binds two Ca2+ ions and is remarkably similar to the C2A-domain. Consistent with these results, but in contrast to previous studies, we find that the C2B-domain binds phospholipids in a Ca2+-dependent manner similarly to the C2A-domain. These results suggest a novel view of synaptotagmin function whereby the two C2-domains cooperate in a common activity, Ca2+-dependent phospholipid binding, to trigger neurotransmitter release.
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The line below this paragraph, {{ABSTRACT_PUBMED_11754837}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11754837 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11754837}}
==About this Structure==
==About this Structure==
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1K5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5W OCA].
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1K5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5W OCA].
==Reference==
==Reference==
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[[Category: Synaptic vesicle exocytosis]]
[[Category: Synaptic vesicle exocytosis]]
[[Category: Synaptotagmin i]]
[[Category: Synaptotagmin i]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:50:16 2008''

Revision as of 06:50, 2 July 2008

Image:1k5w.png

Template:STRUCTURE 1k5w

THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE

Template:ABSTRACT PUBMED 11754837

About this Structure

1K5W is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine., Fernandez I, Arac D, Ubach J, Gerber SH, Shin O, Gao Y, Anderson RG, Sudhof TC, Rizo J, Neuron. 2001 Dec 20;32(6):1057-69. PMID:11754837

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