1k61

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{{STRUCTURE_1k61| PDB=1k61 | SCENE= }}
{{STRUCTURE_1k61| PDB=1k61 | SCENE= }}
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'''MATALPHA2 HOMEODOMAIN BOUND TO DNA'''
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===MATALPHA2 HOMEODOMAIN BOUND TO DNA===
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==Overview==
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Hoogsteen base pairs within duplex DNA typically are only observed in regions containing significant distortion or near sites of drug intercalation. We report here the observation of a Hoogsteen base pair embedded within undistorted, unmodified B-DNA. The Hoogsteen base pair, consisting of a syn adenine base paired with an anti thymine base, is found in the 2.1 A resolution structure of the MATalpha2 homeodomain bound to DNA in a region where a specifically and a non-specifically bound homeodomain contact overlapping sites. NMR studies of the free DNA show no evidence of Hoogsteen base pair formation, suggesting that protein binding favors the transition from a Watson-Crick to a Hoogsteen base pair. Molecular dynamics simulations of the homeodomain-DNA complex support a role for the non-specifically bound protein in favoring Hoogsteen base pair formation. The presence of a Hoogsteen base pair in the crystal structure of a protein-DNA complex raises the possibility that Hoogsteen base pairs could occur within duplex DNA and play a hitherto unrecognized role in transcription, replication and other cellular processes.
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{{ABSTRACT_PUBMED_12466549}}
==About this Structure==
==About this Structure==
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[[Category: Hoogsteen base pair]]
[[Category: Hoogsteen base pair]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:50:18 2008''

Revision as of 06:50, 2 July 2008

Image:1k61.png

Template:STRUCTURE 1k61

MATALPHA2 HOMEODOMAIN BOUND TO DNA

Template:ABSTRACT PUBMED 12466549

About this Structure

1K61 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

A Hoogsteen base pair embedded in undistorted B-DNA., Aishima J, Gitti RK, Noah JE, Gan HH, Schlick T, Wolberger C, Nucleic Acids Res. 2002 Dec 1;30(23):5244-52. PMID:12466549

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