1k68

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{{STRUCTURE_1k68| PDB=1k68 | SCENE= }}
{{STRUCTURE_1k68| PDB=1k68 | SCENE= }}
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'''Crystal Structure of the Phosphorylated Cyanobacterial Phytochrome Response Regulator RcpA'''
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===Crystal Structure of the Phosphorylated Cyanobacterial Phytochrome Response Regulator RcpA===
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==Overview==
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The structures of two response regulators (RRs) from the cyanobacterium Calothrix PCC7601, RcpA and RcpB, were solved to 1.9- and 1.75-A resolution, respectively. RcpA was found in phosphorylated and RcpB in nonphosphorylated form. Both RRs are members of phytochrome-associated, light-sensing two-component signal transduction pathways, based on histidine kinase-mediated receptor autophosphorylation and phosphorelay to a RR. Despite the overall folding similarity to CheY-type RRs ((beta/alpha)(5)-motif), RcpA and RcpB form homodimers, irrespective of their phosphorylation state, giving insight into a signal transduction putatively different from that of other known RRs. Dimerization is accomplished by a C-terminal extension of the RR polypeptide chain, and the surface formed by H4, beta 5, and H5, which constitute a hydrophobic contact area with distinct interactions between residues of either subunit. Sequence alignments reveal that the identified dimerization motif is archetypal for phytochrome-associated RRs, making them a novel subgroup of CheY-type RRs. The protein structures of RcpA and RcpB are compared to the recently presented protein structure of Rcp1 from Synechocystis.
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{{ABSTRACT_PUBMED_15240481}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylated aspartate]]
[[Category: Phosphorylated aspartate]]
[[Category: Response regulator]]
[[Category: Response regulator]]
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Revision as of 06:50, 2 July 2008

Image:1k68.png

Template:STRUCTURE 1k68

Crystal Structure of the Phosphorylated Cyanobacterial Phytochrome Response Regulator RcpA

Template:ABSTRACT PUBMED 15240481

About this Structure

1K68 is a Single protein structure of sequence from Tolypothrix sp. pcc 7601. Full crystallographic information is available from OCA.

Reference

Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators., Benda C, Scheufler C, Tandeau de Marsac N, Gartner W, Biophys J. 2004 Jul;87(1):476-87. PMID:15240481

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