1k6g

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[[Image:1k6g.gif|left|200px]]
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{{Seed}}
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[[Image:1k6g.png|left|200px]]
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{{STRUCTURE_1k6g| PDB=1k6g | SCENE= }}
{{STRUCTURE_1k6g| PDB=1k6g | SCENE= }}
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'''Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing'''
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===Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing===
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==Overview==
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Rnt1p, the yeast orthologue of RNase III, cleaves rRNAs, snRNAs and snoRNAs at a stem capped with conserved AGNN tetraloop. Here we show that 9 bp long stems ending with AGAA or AGUC tetraloops bind to Rnt1p and direct specific but sequence-independent RNA cleavage when provided with stems longer than 13 bp. The solution structures of these two tetraloops reveal a common fold for the terminal loop stabilized by non-canonical A-A or A-C pairs and extensive base stacking. The conserved nucleotides are stacked at the 5' side of the loop, exposing their Watson-Crick and Hoogsteen faces for recognition by Rnt1p. These results indicate that yeast RNase III recognizes the fold of a conserved single-stranded tetraloop to direct specific dsRNA cleavage.
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The line below this paragraph, {{ABSTRACT_PUBMED_11743001}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11743001 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11743001}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6G OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6G OCA].
==Reference==
==Reference==
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[[Category: Yoshizawa, S.]]
[[Category: Yoshizawa, S.]]
[[Category: Rna tetraloop]]
[[Category: Rna tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:51:16 2008''

Revision as of 06:51, 2 July 2008

Image:1k6g.png

Template:STRUCTURE 1k6g

Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing

Template:ABSTRACT PUBMED 11743001

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of conserved AGNN tetraloops: insights into Rnt1p RNA processing., Lebars I, Lamontagne B, Yoshizawa S, Aboul-Elela S, Fourmy D, EMBO J. 2001 Dec 17;20(24):7250-8. PMID:11743001

Page seeded by OCA on Wed Jul 2 09:51:16 2008

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