1k7b

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{{STRUCTURE_1k7b| PDB=1k7b | SCENE= }}
{{STRUCTURE_1k7b| PDB=1k7b | SCENE= }}
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'''NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva'''
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===NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva===
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==Overview==
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The cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A) is Tva, which contains a motif related to repeats in the low density lipoprotein receptor (LDLR) ligand binding repeat (LBr) and which is necessary for viral entry. As observed with LBr repeats of LDLR, the 47 residue LBr domain of Tva (sTva47) requires calcium during oxidative folding to form the correct disulfide bonds, and calcium enhances the structure of correctly oxidized sTva47, as well as its ability to bind the viral envelope protein (Env). However, solution nuclear magnetic resonance studies indicate that, even in the presence of excess calcium, sTva47 exists in an ensemble of conformations. Nonetheless, as reported here, the structure of the predominant sTva47 solution conformer closely resembles that of other LBr repeats, with identical S-S binding topology and octahedral calcium coordination. The location of W48 and other critical residues on the surface suggests a region of the molecule necessary for Env binding and to mediate post-binding events important for ALSV-A cell entry.
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{{ABSTRACT_PUBMED_11768384}}
==About this Structure==
==About this Structure==
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1K7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA].
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1K7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA].
==Reference==
==Reference==
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[[Category: Beta hairpin]]
[[Category: Beta hairpin]]
[[Category: Calcium binding]]
[[Category: Calcium binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:53:53 2008''

Revision as of 06:53, 2 July 2008

Image:1k7b.png

Template:STRUCTURE 1k7b

NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva

Template:ABSTRACT PUBMED 11768384

About this Structure

1K7B is a Single protein structure of sequence from Coturnix coturnix. Full experimental information is available from OCA.

Reference

The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus., Tonelli M, Peters RJ, James TL, Agard DA, FEBS Lett. 2001 Dec 7;509(2):161-8. PMID:11768384

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