1k86

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{{STRUCTURE_1k86| PDB=1k86 | SCENE= }}
{{STRUCTURE_1k86| PDB=1k86 | SCENE= }}
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'''Crystal structure of caspase-7'''
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===Crystal structure of caspase-7===
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==Overview==
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Apoptosis is primarily executed by active caspases, which are derived from the inactive procaspase zymogens through proteolytic cleavage. Here we report the crystal structures of a caspase zymogen, procaspase-7, and an active caspase-7 without any bound inhibitors. Compared to the inhibitor-bound caspase-7, procaspase-7 zymogen exhibits significant structural differences surrounding the catalytic cleft, which precludes the formation of a productive conformation. Proteolytic cleavage between the large and small subunits allows rearrangement of essential loops in the active site, priming active caspase-7 for inhibitor/substrate binding. Strikingly, binding by inhibitors causes a 180 degrees flipping of the N terminus in the small subunit, which interacts with and stabilizes the catalytic cleft. These analyses reveal the structural mechanisms of caspase activation and demonstrate that the inhibitor/substrate binding is a process of induced fit.
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(as it appears on PubMed at http://www.pubmed.gov), where 11701129 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11701129}}
==About this Structure==
==About this Structure==
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[[Category: Caspase]]
[[Category: Caspase]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:25:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:55:45 2008''

Revision as of 06:55, 2 July 2008

Image:1k86.png

Template:STRUCTURE 1k86

Crystal structure of caspase-7

Template:ABSTRACT PUBMED 11701129

About this Structure

1K86 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding., Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y, Cell. 2001 Nov 2;107(3):399-407. PMID:11701129

Page seeded by OCA on Wed Jul 2 09:55:45 2008

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