1k8i

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{{STRUCTURE_1k8i| PDB=1k8i | SCENE= }}
{{STRUCTURE_1k8i| PDB=1k8i | SCENE= }}
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'''CRYSTAL STRUCTURE OF MOUSE H2-DM'''
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===CRYSTAL STRUCTURE OF MOUSE H2-DM===
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==Overview==
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H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor.
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(as it appears on PubMed at http://www.pubmed.gov), where 9768758 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9768758}}
==About this Structure==
==About this Structure==
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[[Category: Marrack, P.]]
[[Category: Marrack, P.]]
[[Category: Mhc]]
[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:56:41 2008''

Revision as of 06:56, 2 July 2008

Image:1k8i.png

Template:STRUCTURE 1k8i

CRYSTAL STRUCTURE OF MOUSE H2-DM

Template:ABSTRACT PUBMED 9768758

About this Structure

1K8I is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:9768758

Page seeded by OCA on Wed Jul 2 09:56:41 2008

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