1k8v

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[[Image:1k8v.jpg|left|200px]]
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{{Seed}}
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[[Image:1k8v.png|left|200px]]
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{{STRUCTURE_1k8v| PDB=1k8v | SCENE= }}
{{STRUCTURE_1k8v| PDB=1k8v | SCENE= }}
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'''The NMR-derived Conformation of Neuropeptide F from Moniezia expansa'''
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===The NMR-derived Conformation of Neuropeptide F from Moniezia expansa===
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==Overview==
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The solution structure of neuropeptide F (NPF), from the flatworm (platyhelminthes) Moniezia expansa, has been determined by (1)H NMR spectroscopy at 800 MHz in 60%/40% CD(3)OH/H(2)O. NPF is the most abundant neuropeptide in platyhelminthes. The secondary structure of NPF contains an alpha helix from residues Lys(14) to Ile(31), while the N terminus, consisting of residues Pro(-2) to Asn(13), and the C-terminus, consisting of residues Gly(32) to Phe(36), are in a random conformation. The structure was calculated by a simulated annealing protocol, and the conformational data are compared to the porcine neuropeptide Y (NPY), a peptide hormone and neurotransmitter. The exact function of NPF is unknown, but structural similarity with porcine NPY indicates that its mode of action is similar. These structural data can serve as a starting point in the design of new antiparasitic drugs.
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The line below this paragraph, {{ABSTRACT_PUBMED_12023801}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12023801 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12023801}}
==About this Structure==
==About this Structure==
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1K8V is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8V OCA].
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1K8V is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8V OCA].
==Reference==
==Reference==
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[[Category: Neuropeptide f]]
[[Category: Neuropeptide f]]
[[Category: Npf]]
[[Category: Npf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:57:52 2008''

Revision as of 06:57, 2 July 2008

Image:1k8v.png

Template:STRUCTURE 1k8v

The NMR-derived Conformation of Neuropeptide F from Moniezia expansa

Template:ABSTRACT PUBMED 12023801

About this Structure

1K8V is a Single protein structure. Full experimental information is available from OCA.

Reference

The NMR-derived conformation of neuropeptide F from Moniezia expansa., Miskolzie M, Kotovych G, J Biomol Struct Dyn. 2002 Jun;19(6):991-8. PMID:12023801

Page seeded by OCA on Wed Jul 2 09:57:52 2008

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