1k99

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{{STRUCTURE_1k99| PDB=1k99 | SCENE= }}
{{STRUCTURE_1k99| PDB=1k99 | SCENE= }}
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'''Solution Structure of the first HMG box in human Upstream binding factor'''
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===Solution Structure of the first HMG box in human Upstream binding factor===
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==Overview==
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Human upstream binding factor is a nucleolar transcription factor involved in transcription by RNA polymerase I. It contains six HMG box domains; the HMG box is a minor groove DNA-binding domain that has been found in hundreds of proteins with different functions. Among the six HMG box domains in hUBF, the first one can bind to the ribosomal promoter specifically by itself and is essential for the whole protein's DNA binding specificity. Here we report the three-dimensional structure of this first HMG box free in solution determined by multidimensional NMR using (13)C,(15)N-labeled protein. Like the previously determined HMG box structures, hUBF HMG box 1 adopts a twisted L-shape consisting of three alpha-helices: helix 1 (17-30) and helix 2 (38-51) pack onto each other to form the short arm, while helix 3 (57-76) is associated with an extended strand N-terminal to helix 1 and forms the long arm. A cluster of conserved residues, in particular the aromatic residues F21, Y49, and Y60, is important to maintain the fold. The short arm is rigid due to extensive hydrophobic interaction between helix 1 and helix 2, while the long arm is less rigid.
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{{ABSTRACT_PUBMED_11969401}}
==About this Structure==
==About this Structure==
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1K99 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K99 OCA].
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1K99 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K99 OCA].
==Reference==
==Reference==
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[[Category: Alpha-helix]]
[[Category: Alpha-helix]]
[[Category: L-shape]]
[[Category: L-shape]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:27:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:58:59 2008''

Revision as of 06:59, 2 July 2008

Image:1k99.png

Template:STRUCTURE 1k99

Solution Structure of the first HMG box in human Upstream binding factor

Template:ABSTRACT PUBMED 11969401

About this Structure

1K99 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the first HMG box domain in human upstream binding factor., Xu Y, Yang W, Wu J, Shi Y, Biochemistry. 2002 Apr 30;41(17):5415-20. PMID:11969401

Page seeded by OCA on Wed Jul 2 09:58:59 2008

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