1k9g

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{{STRUCTURE_1k9g| PDB=1k9g | SCENE= }}
{{STRUCTURE_1k9g| PDB=1k9g | SCENE= }}
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'''Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2'''
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===Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2===
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==Overview==
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Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)(2) in a base-stacking intercalation mode. This is the first DNA intercalator complex, from approximately 90 solved by X-ray crystallography, to bind a nonalternating (pyrimidine-pyrimidine) DNA sequence. The asymmetry of the drug induces a perfect stacking with the asymmetric site, allowing for the stability of the complex in the absence of hydrogen bonding interactions. The crystal structure of this antimalarial drug-DNA complex provides evidence for the first nonalternating intercalation and, as such, provides a basis for the design of new anticancer or antimalarial drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 11731803 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11731803}}
==About this Structure==
==About this Structure==
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[[Category: Wright, C W.]]
[[Category: Wright, C W.]]
[[Category: Dna intercalator complex]]
[[Category: Dna intercalator complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:28:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:59:27 2008''

Revision as of 06:59, 2 July 2008

Image:1k9g.png

Template:STRUCTURE 1k9g

Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2

Template:ABSTRACT PUBMED 11731803

About this Structure

Full crystallographic information is available from OCA.

Reference

The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites., Lisgarten JN, Coll M, Portugal J, Wright CW, Aymami J, Nat Struct Biol. 2002 Jan;9(1):57-60. PMID:11731803

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