1k9j

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[[Image:1k9j.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1k9j| PDB=1k9j | SCENE= }}
{{STRUCTURE_1k9j| PDB=1k9j | SCENE= }}
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'''Complex of DC-SIGNR and GlcNAc2Man3'''
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===Complex of DC-SIGNR and GlcNAc2Man3===
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==Overview==
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Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.
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(as it appears on PubMed at http://www.pubmed.gov), where 11739956 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11739956}}
==About this Structure==
==About this Structure==
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[[Category: C-type lectin]]
[[Category: C-type lectin]]
[[Category: Protein carbohydrate complex]]
[[Category: Protein carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:28:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:59:46 2008''

Revision as of 06:59, 2 July 2008

Image:1k9j.png

Template:STRUCTURE 1k9j

Complex of DC-SIGNR and GlcNAc2Man3

Template:ABSTRACT PUBMED 11739956

About this Structure

1K9J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:11739956

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