This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k9m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k9m.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k9m.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k9m| PDB=1k9m | SCENE= }}
{{STRUCTURE_1k9m| PDB=1k9m | SCENE= }}
-
'''Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui'''
+
===Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui===
-
==Overview==
+
<!--
-
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center. Their location suggests that they inhibit protein synthesis by blocking the egress of nascent polypeptides. The saccharide branch attached to C5 of the lactone rings extends toward the peptidyl transferase center, and the isobutyrate extension of the carbomycin A disaccharide overlaps the A-site. Unexpectedly, a reversible covalent bond forms between the ethylaldehyde substituent at the C6 position of the 16-membered macrolides and the N6 of A2103 (A2062, E. coli). Mutations in 23S rRNA that result in clinical resistance render the binding site less complementary to macrolides.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12150912}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12150912 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12150912}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Antibiotic]]
[[Category: Antibiotic]]
[[Category: Tylosin]]
[[Category: Tylosin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:28:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:59:57 2008''

Revision as of 07:00, 2 July 2008

Image:1k9m.png

Template:STRUCTURE 1k9m

Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui

Template:ABSTRACT PUBMED 12150912

About this Structure

1K9M is a Protein complex structure of sequences from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

The structures of four macrolide antibiotics bound to the large ribosomal subunit., Hansen JL, Ippolito JA, Ban N, Nissen P, Moore PB, Steitz TA, Mol Cell. 2002 Jul;10(1):117-28. PMID:12150912

Page seeded by OCA on Wed Jul 2 09:59:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k9m"
Personal tools