1kaq

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{{STRUCTURE_1kaq| PDB=1kaq | SCENE= }}
{{STRUCTURE_1kaq| PDB=1kaq | SCENE= }}
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'''Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase'''
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===Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase===
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==Overview==
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The nadD gene, encoding the enzyme nicotinic acid mononucleotide (NaMN) adenylyltransferase (AT), is essential for the synthesis of NAD and subsequent viability of the cell. The nadD gene in Bacillus subtilis (yqeJ) was identified by sequence homology with other bacterial nadD genes and by biochemical characterization of the gene product. NaMN AT catalyzes the reversible adenylation of both NaMN and the nicotinamide mononucleotide (NMN) but shows specificity for the nicotinate. In contrast to other known NMN ATs, biophysical characterizations reveal it to be a dimer. The NaMN AT crystal structure was determined for both the apo enzyme and product-bound form, to 2.1 and 3.2 A, respectively. The structures reveal a "functional" dimer conserved in both crystal forms and a monomer fold common to members of the nucleotidyl-transferase alpha/beta phosphodiesterase superfamily. A structural comparison with family members suggests a new conserved motif (SXXXX(R/K)) at the N terminus of an alpha-helix, which is not part of the shared fold. Interactions of the nicotinic acid with backbone atoms indicate the structural basis for specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 11704676 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11704676}}
==About this Structure==
==About this Structure==
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[[Category: Naad]]
[[Category: Naad]]
[[Category: Rossman fold]]
[[Category: Rossman fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:30:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:02:46 2008''

Revision as of 07:02, 2 July 2008

Image:1kaq.png

Template:STRUCTURE 1kaq

Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase

Template:ABSTRACT PUBMED 11704676

About this Structure

1KAQ is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase., Olland AM, Underwood KW, Czerwinski RM, Lo MC, Aulabaugh A, Bard J, Stahl ML, Somers WS, Sullivan FX, Chopra R, J Biol Chem. 2002 Feb 1;277(5):3698-707. Epub 2001 Nov 9. PMID:11704676

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