1kcf

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{{STRUCTURE_1kcf| PDB=1kcf | SCENE= }}
{{STRUCTURE_1kcf| PDB=1kcf | SCENE= }}
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'''Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2'''
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===Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2===
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==Overview==
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Resolution of Holliday junctions into separate DNA duplexes requires enzymatic cleavage of an equivalent strand from each contributing duplex at or close to the point of strand exchange. Diverse Holliday junction-resolving enzymes have been identified in bacteria, bacteriophages, archaea and pox viruses, but the only eukaryotic examples identified so far are those from fungal mitochondria. We have now determined the crystal structure of Ydc2 (also known as SpCce1), a Holliday junction resolvase from the fission yeast Schizosaccharomyces pombe that is involved in the maintenance of mitochondrial DNA. This first structure of a eukaryotic Holliday junction resolvase confirms a distant evolutionary relationship to the bacterial RuvC family, but reveals structural features which are unique to the eukaryotic enzymes. Detailed analysis of the dimeric structure suggests mechanisms for junction isomerization and communication between the two active sites, and together with site-directed mutagenesis identifies residues involved in catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 11726496 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11726496}}
==About this Structure==
==About this Structure==
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[[Category: Beta-alpha-beta motif]]
[[Category: Beta-alpha-beta motif]]
[[Category: Ruvc resolvase family]]
[[Category: Ruvc resolvase family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:34:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:07:35 2008''

Revision as of 07:07, 2 July 2008

Image:1kcf.png

Template:STRUCTURE 1kcf

Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2

Template:ABSTRACT PUBMED 11726496

About this Structure

1KCF is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2., Ceschini S, Keeley A, McAlister MS, Oram M, Phelan J, Pearl LH, Tsaneva IR, Barrett TE, EMBO J. 2001 Dec 3;20(23):6601-11. PMID:11726496

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