1ken

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{{STRUCTURE_1ken| PDB=1ken | SCENE= }}
{{STRUCTURE_1ken| PDB=1ken | SCENE= }}
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'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''
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===INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION===
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==Overview==
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We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.
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(as it appears on PubMed at http://www.pubmed.gov), where 11886266 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11886266}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Hemagglutinin]]
[[Category: Hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:38:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:13:32 2008''

Revision as of 07:13, 2 July 2008

Image:1ken.png

Template:STRUCTURE 1ken

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION

Template:ABSTRACT PUBMED 11886266

About this Structure

1KEN is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:11886266

Page seeded by OCA on Wed Jul 2 10:13:32 2008

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