1kfm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1kfm.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1kfm.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1kfm| PDB=1kfm | SCENE= }}
{{STRUCTURE_1kfm| PDB=1kfm | SCENE= }}
-
'''Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants'''
+
===Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants===
-
==Overview==
+
<!--
-
Native proteins exhibit precise geometric packing of atoms in their hydrophobic interiors. Nonetheless, controversy remains about the role of core side-chain packing in specifying and stabilizing the folded structures of proteins. Here we investigate the role of core packing in determining the conformation and stability of the Lpp-56 trimerization domain. The X-ray crystal structures of Lpp-56 mutants with alanine substitutions at two and four interior core positions reveal trimeric coiled coils in which the twist of individual helices and the helix-helix spacing vary significantly to achieve the most favored superhelical packing arrangement. Introduction of each alanine "layer" into the hydrophobic core destabilizes the superhelix by 1.4 kcal mol(-1). Although the methyl groups of the alanine residues pack at their optimum van der Waals contacts in the coiled-coil trimer, they provide a smaller component of hydrophobic interactions than bulky hydrophobic side-chains to the thermodynamic stability. Thus, specific side-chain packing in the hydrophobic core of coiled coils are important determinants of protein main-chain conformation and stability.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12054830}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12054830 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12054830}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Protein folding]]
[[Category: Protein folding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:41:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:16:10 2008''

Revision as of 07:16, 2 July 2008

Image:1kfm.png

Template:STRUCTURE 1kfm

Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants

Template:ABSTRACT PUBMED 12054830

About this Structure

1KFM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants., Liu J, Cao W, Lu M, J Mol Biol. 2002 May 3;318(3):877-88. PMID:12054830

Page seeded by OCA on Wed Jul 2 10:16:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kfm"
Personal tools