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1kfn

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{{STRUCTURE_1kfn| PDB=1kfn | SCENE= }}
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'''Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants'''
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===Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants===
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==Overview==
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Native proteins exhibit precise geometric packing of atoms in their hydrophobic interiors. Nonetheless, controversy remains about the role of core side-chain packing in specifying and stabilizing the folded structures of proteins. Here we investigate the role of core packing in determining the conformation and stability of the Lpp-56 trimerization domain. The X-ray crystal structures of Lpp-56 mutants with alanine substitutions at two and four interior core positions reveal trimeric coiled coils in which the twist of individual helices and the helix-helix spacing vary significantly to achieve the most favored superhelical packing arrangement. Introduction of each alanine "layer" into the hydrophobic core destabilizes the superhelix by 1.4 kcal mol(-1). Although the methyl groups of the alanine residues pack at their optimum van der Waals contacts in the coiled-coil trimer, they provide a smaller component of hydrophobic interactions than bulky hydrophobic side-chains to the thermodynamic stability. Thus, specific side-chain packing in the hydrophobic core of coiled coils are important determinants of protein main-chain conformation and stability.
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(as it appears on PubMed at http://www.pubmed.gov), where 12054830 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054830}}
==About this Structure==
==About this Structure==
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[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Protein folding]]
[[Category: Protein folding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:41:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:16:25 2008''

Revision as of 07:16, 2 July 2008

Image:1kfn.png

Template:STRUCTURE 1kfn

Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants

Template:ABSTRACT PUBMED 12054830

About this Structure

1KFN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants., Liu J, Cao W, Lu M, J Mol Biol. 2002 May 3;318(3):877-88. PMID:12054830

Page seeded by OCA on Wed Jul 2 10:16:25 2008

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