1kg0

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[[Image:1kg0.gif|left|200px]]
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{{STRUCTURE_1kg0| PDB=1kg0 | SCENE= }}
{{STRUCTURE_1kg0| PDB=1kg0 | SCENE= }}
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'''Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1'''
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===Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1===
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==Overview==
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Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent infections, and is associated with a variety of human tumors. The EBV gp42 glycoprotein binds MHC class II molecules, playing a critical role in infection of B lymphocytes. EBV gp42 belongs to the C-type lectin superfamily, with homology to NK receptors of the immune system. We report the crystal structure of gp42 bound to the human MHC class II molecule HLA-DR1. The gp42 binds HLA-DR1 using a surface site that is distinct from the canonical lectin and NK receptor ligand binding sites. At the canonical ligand binding site, gp42 forms a large hydrophobic groove, which could interact with other ligands necessary for EBV entry, providing a mechanism for coupling MHC recognition and membrane fusion.
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(as it appears on PubMed at http://www.pubmed.gov), where 11864610 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11864610}}
==About this Structure==
==About this Structure==
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[[Category: Mhc]]
[[Category: Mhc]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:42:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:17:32 2008''

Revision as of 07:17, 2 July 2008

Image:1kg0.png

Template:STRUCTURE 1kg0

Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1

Template:ABSTRACT PUBMED 11864610

About this Structure

1KG0 is a Protein complex structure of sequences from Homo sapiens and Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1., Mullen MM, Haan KM, Longnecker R, Jardetzky TS, Mol Cell. 2002 Feb;9(2):375-85. PMID:11864610

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