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1kgj

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{{STRUCTURE_1kgj| PDB=1kgj | SCENE= }}
{{STRUCTURE_1kgj| PDB=1kgj | SCENE= }}
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'''Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)'''
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===Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)===
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==Overview==
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The crystal structure of rat transthyretin (rTTR) complex with the dibromoflavone EMD21388 was determined to 2.3 A resolution and refined to R = 0.203 and Rfree = 0.288. Two different orientations of EMD21388, which differ in the channel penetration by 1.6 A, were found in the A/C binding site of rTTR. The single ligand position observed in the BID site is intermediate between the two positions found in the A/C site. The position of the dibromoflavone in the B/D site is similar to that reported for dibromoaurone in human TTR. The bromine atoms of EMD21388 form strong interactions in the P3 and P3' pockets of rTTR. Due to the different molecular architectures of both ligands, dibromoflavone forms only one interaction with Lys-15 near the channel entrance, while direct interactions with the pair of Lys-15 were reported for dibromoaurone. The C3* methyl group of EMD21388 mediates the bridging interactions between two TTR subunits in the P2 pockets. The interactions of the O2* hydroxyl group of dibromoaurone with the Thr-119 side chain in the P3 pockets are not matched by similar interactions in EMD21388. Both these alternative interactions can explain the competitive binding of 3',5'-dibromoflavonoids to transthyretin.
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{{ABSTRACT_PUBMED_11995999}}
==About this Structure==
==About this Structure==
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[[Category: Thyroid hormone]]
[[Category: Thyroid hormone]]
[[Category: Transport]]
[[Category: Transport]]
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Revision as of 07:18, 2 July 2008

Image:1kgj.png

Template:STRUCTURE 1kgj

Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)

Template:ABSTRACT PUBMED 11995999

About this Structure

1KGJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Comparison of binding interactions of dibromoflavonoids with transthyretin., Muziol T, Cody V, Wojtczak A, Acta Biochim Pol. 2001;48(4):885-92. PMID:11995999

Page seeded by OCA on Wed Jul 2 10:18:43 2008

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