This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1kgy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1kgy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1kgy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1kgy| PDB=1kgy | SCENE= }}
{{STRUCTURE_1kgy| PDB=1kgy | SCENE= }}
-
'''Crystal Structure of the EphB2-ephrinB2 complex'''
+
===Crystal Structure of the EphB2-ephrinB2 complex===
-
==Overview==
+
<!--
-
The Eph family of receptor tyrosine kinases and their membrane-anchored ephrin ligands are important in regulating cell-cell interactions as they initiate a unique bidirectional signal transduction cascade whereby information is communicated into both the Eph-expressing and the ephrin-expressing cells. Initially identified as regulators of axon pathfinding and neuronal cell migration, Ephs and ephrins are now known to have roles in many other cell-cell interactions, including those of vascular endothelial cells and specialized epithelia. Here we report the crystal structure of the complex formed between EphB2 and ephrin-B2, determined at 2.7 A resolution. Each Eph receptor binds an ephrin ligand through an expansive dimerization interface dominated by the insertion of an extended ephrin loop into a channel at the surface of the receptor. Two Eph-Ephrin dimers then join to form a tetramer, in which each ligand interacts with two receptors and each receptor interacts with two ligands. The Eph and ephrin molecules are precisely positioned and orientated in these complexes, promoting higher-order clustering and the initiation of bidirectional signalling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11780069}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11780069 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11780069}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Rajashankar, K R.]]
[[Category: Rajashankar, K R.]]
[[Category: Developmental protein]]
[[Category: Developmental protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:44:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:19:41 2008''

Revision as of 07:19, 2 July 2008

Image:1kgy.png

Template:STRUCTURE 1kgy

Crystal Structure of the EphB2-ephrinB2 complex

Template:ABSTRACT PUBMED 11780069

About this Structure

1KGY is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an Eph receptor-ephrin complex., Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB, Nature. 2001 Dec 20-27;414(6866):933-8. PMID:11780069

Page seeded by OCA on Wed Jul 2 10:19:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kgy"
Personal tools