This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1khp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1khp.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1khp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1khp| PDB=1khp | SCENE= }}
{{STRUCTURE_1khp| PDB=1khp | SCENE= }}
-
'''Monoclinic form of papain/ZLFG-DAM covalent complex'''
+
===Monoclinic form of papain/ZLFG-DAM covalent complex===
-
==Overview==
+
<!--
-
The three-dimensional structure of two polymorphs of a ZLFG-CH2-papain covalent complex has been determined by X-ray crystallography. The structures indicate that: (i) the methylene carbon atom of the inhibitor is covalently bound to the Sgamma atom of Cys25 of papain; (ii) the hydrophobic S2 pocket formed by Pro68, Val133, Val157, and Asp158 is occupied by the inhibitor's phenylalanyl P2 side chain; (iii) extensive hydrogen bonding and hydrophobic interactions are responsible for the interaction of the inhibitor with the enzyme. Comparison with similar structures suggests that in covalent complexes preservation of main chain-main chain interactions between the enzyme and the inhibitor may have higher priority than the P-S interactions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15357669}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15357669 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15357669}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Irreversible inhibitor]]
[[Category: Irreversible inhibitor]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:45:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:21:48 2008''

Revision as of 07:21, 2 July 2008

Image:1khp.png

Template:STRUCTURE 1khp

Monoclinic form of papain/ZLFG-DAM covalent complex

Template:ABSTRACT PUBMED 15357669

About this Structure

1KHP is a Single protein structure of sequence from Carica papaya. Full crystallographic information is available from OCA.

Reference

Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor., Janowski R, Kozak M, Jankowska E, Grzonka Z, Jaskolski M, J Pept Res. 2004 Oct;64(4):141-50. PMID:15357669

Page seeded by OCA on Wed Jul 2 10:21:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1khp"
Personal tools