1khr

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[[Image:1khr.gif|left|200px]]
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{{STRUCTURE_1khr| PDB=1khr | SCENE= }}
{{STRUCTURE_1khr| PDB=1khr | SCENE= }}
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'''Crystal Structure of Vat(D) in Complex with Virginiamycin and Coenzyme A'''
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===Crystal Structure of Vat(D) in Complex with Virginiamycin and Coenzyme A===
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==Overview==
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The streptogramin class of antibiotics act to inhibit bacterial protein synthesis, and their semisynthetic derivatives, such as dalfopristin-quinupristin (Synercid), are used to treat serious or life-threatening infections due to multiply antibiotic resistant bacteria. Acquired resistance of the nosocomial pathogen Enterococcus faecium to the group A component of natural and semisynthetic streptogramin mixtures is a prerequisite for the streptogramin resistance phenotype and is mediated by a streptogramin acetyltransferase. The crystal structure of Vat(D), a streptogramin acetyltransferase from a human urinary isolate of E. faecium, has been determined as an apoenzyme and in complex with either acetyl-CoA or virginiamycin M1 and CoA. These structures illustrate the location and arrangement of residues at the active site, and point to His 82 as a residue that may function as a general base. The structural similarity of Vat(D) to the xenobiotic acetyltransferase from Pseudomonas aeruginosa indicates similarities in the catalytic mechanism for these enzymes as well as several shared and distinctive antibiotic binding interactions between these enzymes and their respective substrates. These results reveal the molecular basis for a reaction by which Gram-positive cocci acquire resistance to a last resort antibiotic.
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(as it appears on PubMed at http://www.pubmed.gov), where 11841212 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11841212}}
==About this Structure==
==About this Structure==
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[[Category: Acyltransferase]]
[[Category: Acyltransferase]]
[[Category: Antibiotic resistance]]
[[Category: Antibiotic resistance]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:45:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:21:54 2008''

Revision as of 07:21, 2 July 2008

Image:1khr.png

Template:STRUCTURE 1khr

Crystal Structure of Vat(D) in Complex with Virginiamycin and Coenzyme A

Template:ABSTRACT PUBMED 11841212

About this Structure

1KHR is a Single protein structure of sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics., Sugantino M, Roderick SL, Biochemistry. 2002 Feb 19;41(7):2209-16. PMID:11841212

Page seeded by OCA on Wed Jul 2 10:21:54 2008

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