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1ki0

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[[Image:1ki0.gif|left|200px]]
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{{Seed}}
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[[Image:1ki0.png|left|200px]]
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{{STRUCTURE_1ki0| PDB=1ki0 | SCENE= }}
{{STRUCTURE_1ki0| PDB=1ki0 | SCENE= }}
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'''The X-ray Structure of Human Angiostatin'''
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===The X-ray Structure of Human Angiostatin===
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==Overview==
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Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle lysine-binding sites contain a bound bicine molecule of crystallization while the former of kringle 2 and kringle 3 are cofacial. Moreover, the separation of the kringle 2 and kringle 3 lysiner binding sites is sufficient to accommodate the alpha-helix of the 30 residue peptide VEK-30 found in the kringle 2/VEK-30 complex. Together the three kringles produce a central cavity suggestive of a unique domain where they may function in concert.
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The line below this paragraph, {{ABSTRACT_PUBMED_12054798}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12054798 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054798}}
==About this Structure==
==About this Structure==
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[[Category: Tulinsky, A.]]
[[Category: Tulinsky, A.]]
[[Category: Kringle domain]]
[[Category: Kringle domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:46:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:22:33 2008''

Revision as of 07:22, 2 July 2008

Image:1ki0.png

Template:STRUCTURE 1ki0

The X-ray Structure of Human Angiostatin

Template:ABSTRACT PUBMED 12054798

About this Structure

1KI0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin., Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH, J Mol Biol. 2002 May 10;318(4):1009-17. PMID:12054798

Page seeded by OCA on Wed Jul 2 10:22:33 2008

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