1kjw

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{{STRUCTURE_1kjw| PDB=1kjw | SCENE= }}
{{STRUCTURE_1kjw| PDB=1kjw | SCENE= }}
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'''SH3-Guanylate Kinase Module from PSD-95'''
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===SH3-Guanylate Kinase Module from PSD-95===
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==Overview==
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Membrane-associated guanylate kinases (MAGUKs), such as PSD-95, are modular scaffolds that organize signaling complexes at synapses and other cell junctions. MAGUKs contain PDZ domains, which recruit signaling proteins, as well as a Src homology 3 (SH3) and a guanylate kinase-like (GK) domain, implicated in scaffold oligomerization. The crystal structure of the SH3-GK module from PSD-95 reveals that these domains form an integrated unit: the SH3 fold comprises noncontiguous sequence elements divided by a hinge region and the GK domain. These elements compose two subdomains that can assemble in either an intra- or intermolecular fashion to complete the SH3 fold. We propose a model for MAGUK oligomerization in which complementary SH3 subdomains associate by 3D domain swapping. This model provides a possible mechanism for ligand regulation of oligomerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 11779504 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11779504}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
[[Category: Scaffold]]
[[Category: Scaffold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:49:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:27:00 2008''

Revision as of 07:27, 2 July 2008

Image:1kjw.png

Template:STRUCTURE 1kjw

SH3-Guanylate Kinase Module from PSD-95

Template:ABSTRACT PUBMED 11779504

About this Structure

1KJW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins., McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE, Mol Cell. 2001 Dec;8(6):1291-301. PMID:11779504

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