1kko

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{{STRUCTURE_1kko| PDB=1kko | SCENE= }}
{{STRUCTURE_1kko| PDB=1kko | SCENE= }}
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'''CRYSTAL STRUCTURE OF CITROBACTER AMALONATICUS METHYLASPARTATE AMMONIA LYASE'''
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===CRYSTAL STRUCTURE OF CITROBACTER AMALONATICUS METHYLASPARTATE AMMONIA LYASE===
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==Overview==
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Methylaspartate ammonia lyase (MAL) catalyzes the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. The 1.3 A MAD crystal structure of the dimeric Citrobacter amalonaticus MAL shows that each subunit comprises two domains, one of which adopts the classical TIM barrel fold, with the active site at the C-terminal end of the barrel. Despite very low sequence similarity, the structure of MAL is closely related to those of representative members of the enolase superfamily, indicating that the mechanism of MAL involves the initial abstraction of a proton alpha to the 3-carboxyl of (2S,3S)-3-methylasparic acid to yield an enolic intermediate. This analysis resolves the conflict that had linked MAL to the histidine and phenylalanine ammonia lyase family of enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 11796115 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11796115}}
==About this Structure==
==About this Structure==
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[[Category: Methylaspartate ammonia lyase]]
[[Category: Methylaspartate ammonia lyase]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:51:27 2008''
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Revision as of 07:28, 2 July 2008

Image:1kko.png

Template:STRUCTURE 1kko

CRYSTAL STRUCTURE OF CITROBACTER AMALONATICUS METHYLASPARTATE AMMONIA LYASE

Template:ABSTRACT PUBMED 11796115

About this Structure

1KKO is a Single protein structure of sequence from Citrobacter amalonaticus. Full crystallographic information is available from OCA.

Reference

Insights into enzyme evolution revealed by the structure of methylaspartate ammonia lyase., Levy CW, Buckley PA, Sedelnikova S, Kato Y, Asano Y, Rice DW, Baker PJ, Structure. 2002 Jan;10(1):105-13. PMID:11796115

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