1kl9

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{{STRUCTURE_1kl9| PDB=1kl9 | SCENE= }}
{{STRUCTURE_1kl9| PDB=1kl9 | SCENE= }}
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'''Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha'''
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===Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha===
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==Overview==
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Eukaryotic translation initiation factor 2alpha (eIF2alpha) is a member of the eIF2 heterotrimeric complex that binds and delivers Met-tRNA(i)(Met) to the 40 S ribosomal subunit in a GTP-dependent manner. Phosphorylation/dephosphorylation of eIF2alpha at Ser-51 is the major regulator of protein synthesis in eukaryotic cells. Here, we report the first structural analysis on eIF2, the three-dimensional structure of a 22-kDa N-terminal portion of human eIF2alpha by x-ray diffraction at 1.9 A resolution. This structure contains two major domains. The N terminus is a beta-barrel with five antiparallel beta-strands in an oligonucleotide binding domain (OB domain) fold. The phosphorylation site (Ser-51) is on the loop connecting beta3 and beta4 in the OB domain. A helical domain follows the OB domain, and the first helix has extensive interactions, including a disulfide bridge, to fix its orientation with respect to the OB domain. The two domains meet along a negatively charged groove with highly conserved residues, indicating a likely site for protein-protein interaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_11859078}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11859078 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11859078}}
==About this Structure==
==About this Structure==
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[[Category: Helical domain]]
[[Category: Helical domain]]
[[Category: Ob fold]]
[[Category: Ob fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:52:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:30:15 2008''

Revision as of 07:30, 2 July 2008

Image:1kl9.png

Template:STRUCTURE 1kl9

Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha

Template:ABSTRACT PUBMED 11859078

About this Structure

1KL9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha., Nonato MC, Widom J, Clardy J, J Biol Chem. 2002 May 10;277(19):17057-61. Epub 2002 Feb 21. PMID:11859078

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