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1klx

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{{STRUCTURE_1klx| PDB=1klx | SCENE= }}
{{STRUCTURE_1klx| PDB=1klx | SCENE= }}
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'''Helicobacter pylori cysteine rich protein B (hcpB)'''
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===Helicobacter pylori cysteine rich protein B (hcpB)===
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==Overview==
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Colonization of the gastric mucosa with the spiral-shaped Gram-negative proteobacterium Helicobacter pylori is probably the most common chronic infection in humans. The genomes of H. pylori strains J99 and 26695 have been completely sequenced. Functional and three-dimensional structural information is available for less than one third of all open reading frames. We investigated the function and three-dimensional structure of a member from a family of cysteine-rich hypothetical proteins that are unique to H. pylori and Campylobacter jejuni. The structure of H. pylori cysteine-rich protein (Hcp) B possesses a modular architecture consisting of four alpha/alpha-motifs that are cross-linked by disulfide bridges. The Hcp repeat is similar to the tetratricopeptide repeat, which is frequently found in protein/protein interactions. In contrast to the tetratricopeptide repeat, the Hcp repeat is 36 amino acids long. HcpB is capable of binding and hydrolyzing 6-amino penicillinic acid and 7-amino cephalosporanic acid derivatives. The HcpB fold is distinct from the fold of any known penicillin-binding protein, indicating that the Hcp proteins comprise a new family of penicillin-binding proteins. The putative penicillin binding site is located in an amphipathic groove on the concave side of the molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 11777911 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11777911}}
==About this Structure==
==About this Structure==
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[[Category: Right handed super helix]]
[[Category: Right handed super helix]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:53:58 2008''
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Revision as of 07:32, 2 July 2008

Image:1klx.png

Template:STRUCTURE 1klx

Helicobacter pylori cysteine rich protein B (hcpB)

Template:ABSTRACT PUBMED 11777911

About this Structure

1KLX is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein., Luthy L, Grutter MG, Mittl PR, J Biol Chem. 2002 Mar 22;277(12):10187-93. Epub 2002 Jan 2. PMID:11777911

Page seeded by OCA on Wed Jul 2 10:32:00 2008

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