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| - | [[Image:1knb.gif|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_1knb| PDB=1knb | SCENE= }} | | {{STRUCTURE_1knb| PDB=1knb | SCENE= }} |
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| - | '''CRYSTAL STRUCTURE OF THE RECEPTOR-BINDING DOMAIN OF ADENOVIRUS TYPE 5 FIBER PROTEIN AT 1.7 ANGSTROMS RESOLUTION'''
| + | ===CRYSTAL STRUCTURE OF THE RECEPTOR-BINDING DOMAIN OF ADENOVIRUS TYPE 5 FIBER PROTEIN AT 1.7 ANGSTROMS RESOLUTION=== |
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| - | ==Overview==
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| - | BACKGROUND: Adenoviral infection begins with the binding of virion to the surface of host cells. Specific attachment is achieved through interactions between host-cell receptors and the adenovirus fiber protein and is mediated by the globular carboxy-terminal domain of the adenovirus fiber protein, termed the carboxy-terminal knob domain. RESULTS: The crystal structure of the carboxy-terminal knob domain of the adenovirus type 5 (Ad5) fiber protein has been determined at 1.7 A resolution. Each knob monomer forms an eight-stranded antiparallel beta-sandwich structure. In the crystal lattice, the knob monomers form closely interacting trimers which possess a deep surface depression centered around the three-fold molecular symmetry axis and three symmetry-related valleys. CONCLUSIONS: The amino acid residues lining the wall of the central surface depression and the three symmetry-related floors of the valleys are strictly conserved in the knob domains of Ad5 and adenovirus type 2 (Ad2) fiber proteins, which share the same cellular receptor. The beta-sandwich structure of the knob monomer demonstrates a unique folding topology which is different from that of other known antiparallel beta-sandwich structures. The large buried surface area and numerous polar interactions in the trimer indicate that this form of the knob protein is predominant in solution, suggesting a possible assembly pathway for the native fiber protein.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_7704534}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 7704534 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_7704534}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Xia, D.]] | | [[Category: Xia, D.]] |
| | [[Category: Cell receptor recognition]] | | [[Category: Cell receptor recognition]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:39 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:35:23 2008'' |
Revision as of 07:35, 2 July 2008
Template:STRUCTURE 1knb
CRYSTAL STRUCTURE OF THE RECEPTOR-BINDING DOMAIN OF ADENOVIRUS TYPE 5 FIBER PROTEIN AT 1.7 ANGSTROMS RESOLUTION
Template:ABSTRACT PUBMED 7704534
About this Structure
1KNB is a Single protein structure of sequence from Human adenovirus 5. Full crystallographic information is available from OCA.
Reference
Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution., Xia D, Henry LJ, Gerard RD, Deisenhofer J, Structure. 1994 Dec 15;2(12):1259-70. PMID:7704534
Page seeded by OCA on Wed Jul 2 10:35:23 2008
