1kne

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[[Image:1kne.gif|left|200px]]
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{{STRUCTURE_1kne| PDB=1kne | SCENE= }}
{{STRUCTURE_1kne| PDB=1kne | SCENE= }}
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'''Chromo domain of HP1 complexed with histone H3 tail containing trimethyllysine 9'''
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===Chromo domain of HP1 complexed with histone H3 tail containing trimethyllysine 9===
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==Overview==
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The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing. The histone tail inserts as a beta strand, completing the beta-sandwich architecture of the chromodomain. The methylammonium group is caged by three aromatic side chains, whereas adjacent residues form discerning contacts with one face of the chromodomain. Comparison of dimethyl- and trimethyllysine-containing complexes suggests a role for cation-pi and van der Waals interactions, with trimethylation slightly improving the binding affinity.
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The line below this paragraph, {{ABSTRACT_PUBMED_11859155}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11859155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11859155}}
==About this Structure==
==About this Structure==
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[[Category: Methyllysine]]
[[Category: Methyllysine]]
[[Category: Trimethyllysine]]
[[Category: Trimethyllysine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:35:39 2008''

Revision as of 07:35, 2 July 2008

Image:1kne.png

Template:STRUCTURE 1kne

Chromo domain of HP1 complexed with histone H3 tail containing trimethyllysine 9

Template:ABSTRACT PUBMED 11859155

About this Structure

1KNE is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail., Jacobs SA, Khorasanizadeh S, Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21. PMID:11859155

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