1koa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1koa.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1koa.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1koa| PDB=1koa | SCENE= }}
{{STRUCTURE_1koa| PDB=1koa | SCENE= }}
-
'''TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS'''
+
===TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS===
-
==Overview==
+
<!--
-
The myosin-associated giant protein kinases twitchin and titin are composed predominantly of fibronectin- and immunoglobulin-like modules. We report the crystal structures of two autoinhibited twitchin kinase fragments, one from Aplysia and a larger fragment from Caenorhabditis elegans containing an additional C-terminal immunoglobulin-like domain. The structure of the longer fragment shows that the immunoglobulin domain contacts the protein kinase domain on the opposite side from the catalytic cleft, laterally exposing potential myosin binding residues. Together, the structures reveal the cooperative interactions between the autoregulatory region and the residues from the catalytic domain involved in protein substrate binding, ATP binding, catalysis and the activation loop, and explain the differences between the observed autoinhibitory mechanism and the one found in the structure of calmodulin-dependent kinase I.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9003756}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9003756 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9003756}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Twitchin]]
[[Category: Twitchin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:58:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:38:19 2008''

Revision as of 07:38, 2 July 2008

Image:1koa.png

Template:STRUCTURE 1koa

TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS

Template:ABSTRACT PUBMED 9003756

About this Structure

1KOA is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Giant protein kinases: domain interactions and structural basis of autoregulation., Kobe B, Heierhorst J, Feil SC, Parker MW, Benian GM, Weiss KR, Kemp BE, EMBO J. 1996 Dec 16;15(24):6810-21. PMID:9003756

Page seeded by OCA on Wed Jul 2 10:38:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1koa"
Personal tools