1kod

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[[Image:1kod.jpg|left|200px]]
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{{Seed}}
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[[Image:1kod.png|left|200px]]
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{{STRUCTURE_1kod| PDB=1kod | SCENE= }}
{{STRUCTURE_1kod| PDB=1kod | SCENE= }}
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'''RNA APTAMER COMPLEXED WITH CITRULLINE, NMR'''
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===RNA APTAMER COMPLEXED WITH CITRULLINE, NMR===
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==Overview==
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In a previous study, an RNA aptamer for the specific recognition of arginine was evolved from a parent sequence that bound citrulline specifically. The two RNAs differ at only 3 positions out of 44. The solution structures of the two aptamers complexed to their cognate amino acids have now been determined by two-dimensional nuclear magnetic resonance spectroscopy. Both aptamers contain two asymmetrical internal loops that are not well ordered in the free RNA but that fold into a compact structure upon ligand binding. Those nucleotides common to both RNAs include a conserved cluster of purine residues, three of which form an uneven plane containing a G:G pair, and two other residues nearly perpendicular to that surface. Two of the three variant nucleotides are stacked on the cluster of purines and form a triple contact to the amino acid side chain, whereas the edge of the third variant nucleotide is capping the binding pocket.
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The line below this paragraph, {{ABSTRACT_PUBMED_8650546}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8650546 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8650546}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOD OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOD OCA].
==Reference==
==Reference==
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[[Category: In vitro selected rna]]
[[Category: In vitro selected rna]]
[[Category: Rna aptamer]]
[[Category: Rna aptamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:58:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:38:51 2008''

Revision as of 07:38, 2 July 2008

Image:1kod.png

Template:STRUCTURE 1kod

RNA APTAMER COMPLEXED WITH CITRULLINE, NMR

Template:ABSTRACT PUBMED 8650546

About this Structure

Full experimental information is available from OCA.

Reference

Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy., Yang Y, Kochoyan M, Burgstaller P, Westhof E, Famulok M, Science. 1996 May 31;272(5266):1343-7. PMID:8650546

Page seeded by OCA on Wed Jul 2 10:38:51 2008

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