1hv7

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(New page: 200px<br /><applet load="1hv7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hv7, resolution 1.7&Aring;" /> '''PORCINE PANCREATIC EL...)
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Revision as of 14:43, 20 November 2007

Image:1hv7.jpg

1hv7, resolution 1.7Å

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PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A

Overview

The discovery of a potent intracellular inhibitor of human neutrophil, elastase which is orally active and has a long duration of action is, described. The pharmacodynamic and pharmacokinetic properties of a, trans-lactam development candidate, GW311616A, are described.

About this Structure

1HV7 is a Single protein structure of sequence from Sus scrofa with SO4 and 616 as ligands. Active as Pancreatic elastase, with EC number 3.4.21.36 Full crystallographic information is available from OCA.

Reference

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate., Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H, Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. PMID:11294386

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