This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1kq1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1kq1.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1kq1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1kq1| PDB=1kq1 | SCENE= }}
{{STRUCTURE_1kq1| PDB=1kq1 | SCENE= }}
-
'''1.55 A Crystal structure of the pleiotropic translational regulator, Hfq'''
+
===1.55 A Crystal structure of the pleiotropic translational regulator, Hfq===
-
==Overview==
+
<!--
-
In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences. To elucidate the mechanisms of target recognition and translation regulation by Hfq, we determined the crystal structures of the Staphylococcus aureus Hfq and an Hfq-RNA complex to 1.55 and 2.71 A resolution, respectively. The structures reveal that Hfq possesses the Sm-fold previously observed only in eukaryotes and archaea. However, unlike these heptameric Sm proteins, Hfq forms a homo-hexameric ring. The Hfq-RNA structure reveals that the single-stranded hepta-oligoribonucleotide binds in a circular conformation around a central basic cleft, whereby Tyr42 residues from adjacent subunits stack with six of the bases, and Gln8, outside the Sm motif, provides key protein-base contacts. Such binding suggests a mechanism for Hfq function.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12093755}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12093755 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12093755}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Sm motif]]
[[Category: Sm motif]]
[[Category: Translational regulator]]
[[Category: Translational regulator]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:01:53 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:44:40 2008''

Revision as of 07:44, 2 July 2008

Image:1kq1.png

Template:STRUCTURE 1kq1

1.55 A Crystal structure of the pleiotropic translational regulator, Hfq

Template:ABSTRACT PUBMED 12093755

About this Structure

1KQ1 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein., Schumacher MA, Pearson RF, Moller T, Valentin-Hansen P, Brennan RG, EMBO J. 2002 Jul 1;21(13):3546-56. PMID:12093755

Page seeded by OCA on Wed Jul 2 10:44:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kq1"
Personal tools