1kq8

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[[Image:1kq8.jpg|left|200px]]
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{{STRUCTURE_1kq8| PDB=1kq8 | SCENE= }}
{{STRUCTURE_1kq8| PDB=1kq8 | SCENE= }}
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'''Solution Structure of Winged Helix Protein HFH-1'''
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===Solution Structure of Winged Helix Protein HFH-1===
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==Overview==
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The hepatocyte nuclear factor 3 (HNF-3)/fork head (fkh) family contains a large number of transcription factors that recognize divergent DNA sequences via a winged helix binding motif. HNF-3/fkh proteins show a broad profile of DNA sequence-specificity in which one DNA sequence can be recognized by more than one HNF-3/fkh protein and each individual HNF-3/fkh protein has several DNA binding sequences. In this study, heteronuclear NMR methods were used to study the structures of the DNA binding domain of a conserved winged helix protein HFH-1 and its DNA complexes. The structural comparison of winged helix proteins HFH-1 and Genesis and their DNA complexes indicates that even two highly conserved HNF-3 family members can adopt different local structures when they contact an identical DNA binding sequence, while one of these two HNF-3 proteins seems to adopt only slightly different structures on different DNA binding sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 11876636 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11876636}}
==About this Structure==
==About this Structure==
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1KQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ8 OCA].
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1KQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ8 OCA].
==Reference==
==Reference==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: Winged helix protein]]
[[Category: Winged helix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:02:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:45:31 2008''

Revision as of 07:45, 2 July 2008

Image:1kq8.png

Template:STRUCTURE 1kq8

Solution Structure of Winged Helix Protein HFH-1

Template:ABSTRACT PUBMED 11876636

About this Structure

1KQ8 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence., Sheng W, Rance M, Liao X, Biochemistry. 2002 Mar 12;41(10):3286-93. PMID:11876636

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