1kql

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{{STRUCTURE_1kql| PDB=1kql | SCENE= }}
{{STRUCTURE_1kql| PDB=1kql | SCENE= }}
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'''Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution'''
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===Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution===
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==Overview==
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Contraction in striated and cardiac muscles is regulated by the motions of a Ca(2+)-sensitive tropomyosin/troponin switch. In contrast, troponin is absent in other muscle types and in nonmuscle cells, and actomyosin regulation is myosin-linked. Here we report an unusual crystal structure at 2.7 A of the C-terminal 31 residues of rat striated-muscle alpha-tropomyosin (preceded by a fragment of the GCN4 leucine zipper). The C-terminal 22 residues (263-284) of the structure do not form a two-stranded alpha-helical coiled coil as does the rest of the molecule, but here the alpha-helices splay apart and are stabilized by the formation of a tail-to-tail dimer with a symmetry-related molecule. The site of splaying involves a small group of destabilizing core residues that is present only in striated muscle tropomyosin isoforms. These results reveal a specific recognition site for troponin T and clarify the physical basis for the unique regulatory mechanism of striated muscles.
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(as it appears on PubMed at http://www.pubmed.gov), where 12032291 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12032291}}
==About this Structure==
==About this Structure==
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[[Category: Thin filament]]
[[Category: Thin filament]]
[[Category: Tropomyosin]]
[[Category: Tropomyosin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:03:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:47:01 2008''

Revision as of 07:47, 2 July 2008

Image:1kql.png

Template:STRUCTURE 1kql

Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution

Template:ABSTRACT PUBMED 12032291

About this Structure

1KQL is a Single protein structure of sequence from Saccharomyces cerevisiae and rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site., Li Y, Mui S, Brown JH, Strand J, Reshetnikova L, Tobacman LS, Cohen C, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7378-83. PMID:12032291

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